Condition: Cancer · Malignancies Multiple · Malignant Solid Tumor · Sponsor: University Health Network, Toronto
This study will collect data on Canadian cancer patients that have uncommon/rare changes in their tumours, such as alterations/rearrangements in the genetic material inside cells - known as deoxyribonucleic acid, or DNA, which acts as a map and gives directions to the cells on how to make other substances the body needs - because some of these changes have been found to respond to different drugs that help to stop the cancer. These rare changes occur in genes such as but not limited to ALK, EGFR, ROS1, BRAF, and NTRK which have targeted drugs in a family known as tyrosine kinase inhibitors (TKIs), and KRAS G12C mutation, which now has a targeted inhibitor drug therapy for patients with non small cell lung cancer (NSCLC). The goals for the study are to compare the natural history of such cancers and the treatment outcomes, including toxicities and patient-reported outcomes, for the different therapies.
This description comes directly from the study's public registry record.
Faisal Al-Agha, BSc · 416-946-4501 · faisal.al-agha@uhn.ca
Roula Raptis, MSc · 416-864-6060 · Roula.Raptis@unityhealth.to
Always discuss trial participation with your own doctor first.
| Tom Baker Cancer Centre - University of Calgary - Alberta Health Services | Calgary, Alberta, Canada | Recruiting |
| Cross Cancer Institute, University of Alberta - Alberta Health Services | Edmonton, Alberta, Canada | Not Yet Recruiting |
| BC Cancer | Vancouver, British Columbia, Canada | Recruiting |
| CancerCare Manitoba/University of Manitoba | Winnipeg, Manitoba, Canada | Recruiting |
| Dr. Everett Chalmers Regional Hospital | Fredericton, New Brunswick, Canada | Recruiting |
| Dr. H. Bliss Murphy Cancer Centre | St. John's, Newfoundland and Labrador, Canada | Not Yet Recruiting |
| Queen Elizabeth II (QEII) Health Sciences Centre | Halifax, Nova Scotia, Canada | Recruiting |
| William Osler Health System - Brampton Civic Hospital | Brampton, Ontario, Canada | Recruiting |
| Health Sciences North | Greater Sudbury, Ontario, Canada | Recruiting |
| Hamilton Health Sciences - Juravinski Cancer Centre | Hamilton, Ontario, Canada | Recruiting |
| Kingston Health Sciences Centre (KHSC) | Kingston, Ontario, Canada | Recruiting |
| Lawson Health Research Institute - London Health Sciences Centre | London, Ontario, Canada | Recruiting |
+ 15 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04151342