Condition: Tuberculous Meningitis · Sponsor: ANRS, Emerging Infectious Diseases
INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults with or without HIV-infection in sub-Saharan Africa: * Intensified TBM treatment with high-dose rifampicin and linezolid, compared to WHO standard TBM treatment. * Aspirin, compared to not receiving aspirin. The trial will be open-label for anti-TB treatment and placebo-controlled for aspirin treatment.
This description comes directly from the study's public registry record.
Fabrice Bonnet, M.D., Ph.D. · +33 (0)5 56 79 58 26 · fabrice.bonnet@chu-bordeaux.fr
Xavier Anglaret, M.D., Ph.D. · +33 (0)5 57 57 12 58 · xavier.anglaret@u-bordeaux.fr
Always discuss trial participation with your own doctor first.
| Cocody University Hospital | Abidjan, Côte d’Ivoire | Not Yet Recruiting |
| Treichville University Hospital | Abidjan, Côte d’Ivoire | Recruiting |
| Yopougon University Hospital | Abidjan, Côte d’Ivoire | Not Yet Recruiting |
| University Hospital Joseph Raseta Befelatanana | Antananarivo, Madagascar | Recruiting |
| University Hospital Tambohobe | Fianarantsoa, Madagascar | Recruiting |
| Morafeno University Hospital | Toamasina, Madagascar | Not Yet Recruiting |
| Kayelitsha District Hospital | Cape Town, South Africa | Recruiting |
| Mitchells Plain Hospital | Cape Town, South Africa | Recruiting |
| New Somerset Hospital | Cape Town, South Africa | Recruiting |
| Dora Nginza Hospital | Port Elizabeth, South Africa | Recruiting |
| Livingstone and PE Central Hospitals | Port Elizabeth, South Africa | Recruiting |
| Mbarara Regional Reference Hospital | Mbarara, Uganda | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04145258