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Study identifier: NCT04142996 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparing Uni- and Bi-lateral TBS in Major Depression

Condition: Major Depressive Episode  ·  Sponsor: The Royal Ottawa Mental Health Centre

PhaseNA
Planned participants256
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS) is a very promising new treatment for major depression that allows a 15-fold reduction in duration of daily sessions. However, no large scale naturalistic study has assessed the superiority of bilateral TBS in comparison with unilateral left TBS. In fact, no TBS study thus far has included both unipolar and bipolar depression, or other psychiatric comorbidities such as anxiety. Maintenance has yet to be studied with TBS, along with an effective maintenance protocol to prevent relapse. Our study aims to explore and address these gaps.

This description comes directly from the study's public registry record.

Talk to the study team

Stacey Shim, MSc  ·  613-722-6521  ·  stacey.shim@theroyal.ca

Always discuss trial participation with your own doctor first.

Locations (1)

The Royal Ottawa Mental Health CentreOttawa, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT04142996