Condition: Kidney Transplant Recipient Response to Shingrix Vaccine · Kidney Failure · Kidney Failure, Chronic · Sponsor: University of Colorado, Denver
The goal of this clinical trial is to learn how well the shingles vaccine (Shingrix) works and how safe it is in adults with kidney failure who are waiting for a kidney transplant, including those who later receive a transplant. The study also aims to find out whether giving an extra (third) dose of the vaccine after transplant improves protection. The main questions it aims to answer are: How strong is the body's immune response to the vaccine at different time points (about 1 month, 2 years, and 3 years after vaccination) in people waiting for a kidney transplant? Does a third dose of the vaccine after transplant improve the immune response compared to not receiving a third dose? How long does protection from the vaccine last before and after transplant? How safe is the vaccine in this group, including whether it affects transplant-related immune markers? Researchers will compare people who receive a third dose of the vaccine after transplant to those who do not receive a third dose, as well as to results from similar groups studied in the past, to see if the extra dose improves immune protection. Participants will: Be screened to see if they can take part in the study Attend about 3 to 6 study visits over approximately 30 to 37 months Receive two doses of the shingles vaccine if they have not already been vaccinated, or complete study assessments if they were vaccinated before joining If they receive a kidney transplant during the study, be randomly assigned (by c…
This description comes directly from the study's public registry record.
Tori Rutherford, RN BSN · 303-724-2454 · tori.rutherford@childrenscolorado.org
Always discuss trial participation with your own doctor first.
| University of Colorado Anschutz | Aurora, Colorado, United States | Recruiting |
| Emory University | Atlanta, Georgia, United States | Recruiting |
| Brigham and Women's Hospital | Boston, Massachusetts, United States | Recruiting |
| Baylor College of Medicine | Houston, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04128189