Condition: Malignant Melanoma · Sponsor: A.J.M. van den Eertwegh
Currently, there is no widely used adjuvant treatment available to improve survival after surgical excision of a primary melanoma. In a previous study, loco-regional and systemic immune stimulations, as well as favourable clinical outcomes in terms of sentinel lymph node (SLN) tumor status and recurrence-free survival (RFS) in patients with clinical stage I-II melanoma who received a low dose of toll-like receptor 9 (TLR-9) CPG7909 (CpG-B ODN) intradermally at the excision site of the primary tumor prior to SLN biopsy (SNB) were described. In this phase II trial the investigators had investigated the clinical activity of a next-generation CpG-ODN, IMO-2125, and it's ability to induce loco-regional and systemic immune stimulation in pT3-4 cN0M0 melanoma patients who are scheduled to undergo a combined re-excision and SNB is
This description comes directly from the study's public registry record.
Jessica CL Notohardjo, MD · +3120 4444881 · intrim@vumc.nl
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| VU Medical Centere | Amsterdam, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04126876