Condition: Testicular Cancer · Sponsor: University Medical Center Groningen
Cisplatin-combination chemotherapy causes inevitably DNA damage by platinum-DNA adduct formation of both tumor cells but also healthy cells. It therefore stands to reason that testicular cancer treatment causes an increased burden of senescent cells, which causes upregulation of the SASP resulting in a pro-inflammatory phenotype. The investigators hypothesize that this may be an important mechanism behind development of late effects and an early ageing phenotype after treatment for testicular cancer.
This description comes directly from the study's public registry record.
J. A. Gietema, prof. · +31 50 361 2821 · j.a.gietema@umcg.nl
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| University Medical Center Groningen | Groningen, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04113122