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Study identifier: NCT04111978 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO)

Condition: Ovarian Neoplasm Epithelial · Fallopian Tube Neoplasms · Peritoneal Neoplasms  ·  Sponsor: Swiss GO Trial Group

PhasePhase 3
Planned participants540
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy of addition of letrozole to the standard maintenance therapy in subjects following a primary diagnosis of Estrogen-receptor (ER) positive high and low grade epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer) and subsequent primary treatment surgery and chemotherapy. Half of the participants will receive to the standard maintenance treatment, letrozole, whilst the other half receives placebo. The study's primary hypothesis is that the treatment with letrozole increases progression free survival in comparison to the maintenance standard treatment (superiority trial).

This description comes directly from the study's public registry record.

Talk to the study team

McLaughlin, PhD  ·  +41 61 328 42 04  ·  mclaughlin@swiss-go.ch

Vogel, PhD  ·  +41 61 3284203  ·  vogel@swiss-go.ch

Always discuss trial participation with your own doctor first.

Locations (53)

Krankenhaus der Barmherzigen Brüder GrazGraz, AustriaRecruiting
Medizinische Universität GrazGraz, AustriaRecruiting
Medizinische Universität InnsbruckInnsbruck, AustriaRecruiting
Landeskrankenhaus Hochsteiermark LeobenLeoben, AustriaRecruiting
Ordensklinikum Linz Barmherzige SchwesternLinz, AustriaRecruiting
Universitätsklinikum SalzburgSalzburg, AustriaRecruiting
Medizinische Universität WienVienna, AustriaRecruiting
Klinik Hietzing WienVienna, AustriaRecruiting
Charité - Universitätsmedizin Berlin Campus Virchow KlinikumBerlin, GermanyRecruiting
St. Elisabeth-KrankenhausCologne, GermanyRecruiting
Donauisar KlinikumDeggendorf, GermanyRecruiting
Universitätsklinikum Carl Gustav Carus DresdenDresden, GermanyActive Not Recruiting

+ 41 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04111978