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Study identifier: NCT04104776 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Condition: Advanced Solid Tumor · Diffuse Large B Cell Lymphoma · Lymphoma, T-Cell  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants300
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of DZR123 (Tulmimetostat, CPI-0209), both as monotherapy and in combination with enzalutamide, in patients with advanced solid tumors and lymphomas.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Always discuss trial participation with your own doctor first.

Locations (81)

H. Lee Moffitt Cancer Center and Research InstituteTampa, Florida, United StatesWithdrawn
Emory University School of MedicineAtlanta, Georgia, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesRecruiting
Loyola University Medical CenterMaywood, Illinois, United StatesWithdrawn
University of Maryland Medical CtrBaltimore, Maryland, United StatesWithdrawn
Massachusetts General Hospital (MGH)Boston, Massachusetts, United StatesRecruiting
Dana Farber Cancer Institute (HARVARD)Boston, Massachusetts, United StatesCompleted
University of Michigan Rogel Cancer CenterAnn Arbor, Michigan, United StatesWithdrawn
Hackensack University Medical CenterHackensack, New Jersey, United StatesCompleted
Roswell Park Cancer InstituteBuffalo, New York, United StatesWithdrawn
NYU Langone Medical CenterNew York, New York, United StatesCompleted
Weill Medical College of Cornell UniversityNew York, New York, United StatesWithdrawn

+ 69 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04104776