Condition: Conversion Disorder · Sponsor: Centre Hospitalier Universitaire de Nīmes
Conversion disorder refers to impaired voluntary motor or sensory functions that are not compatible with a well-known neurological condition. This disorder affects up to 30% of hospitalized patients in neurology departments and symptoms persist in 35% of patients after 12 years of evolution. Despite a poor prognosis, no treatments have been validated to date. The development of non-invasive brain stimulation techniques has allowed the creation of treatments focused on dysfunctional brain regions associated with motor conversion disorder. Hypoactivation of prefrontal dorso-lateral cortex underlies the course of functional motor symptoms. Results of the HYCORE study conducted at Nîmes University Hospital (including 20 patients, clinicaltrial.gov NCT02329626) confirmed these results and related hypoactivation of PFDLC to persistent motor disability at 3 months and 6 months follow-up. Activation of the PFDLC could restore executive control and thus promote the recovery of motor symptoms. However, in most repeated Transcranial Magnetic Stimulation (rTMS) the primary motor areas were targeted and the clinical improvement was related to self-suggestion induced by the motor response produced. Among the different techniques, transcranial Direct Current Stimulation (tDCS) is a medical neuromodulation device that delivers a direct, low-intensity electric current to cortical areas, facilitating neuronal activity. Recently, PFDLC stimulation via tDCS has been used to treat several neur…
This description comes directly from the study's public registry record.
Ismael CONEJERO, Dr. · 07 70 21 62 38 · ismael.conejero@gmail.com
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| Centre Hospitalier Universitaire | Nîmes, Gard, France | Recruiting |
| Hôpital La Colombière Service de Psychiatrie | Montpellier, Hérault, France | Not Yet Recruiting |
| CHU de Montpellier Hôpital Gui De Chauliac Service de Neurologie | Montpellier, Hérault, France | Not Yet Recruiting |
| Hôpital Lapeyronie | Montpellier, Hérault, France | Not Yet Recruiting |
| Hospices Civils de Lyon Hôpital Edouard Herriot | Lyon, France | Not Yet Recruiting |
| CHU de Nantes | Nantes, France | Not Yet Recruiting |
| Clinique St Exupery | Toulouse, France | Not Yet Recruiting |
| Hôpital Saint-Antoine Service de Psychiatrie APHP | Paris, Île-de-France Region, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT04097184