Condition: Mitochondrial Myopathies · Mitochondrial Diseases · Sponsor: Children's Hospital of Philadelphia
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM). There is currently a growing number of potential new treatments to be tested through MM clinical intervention trials, which has created a pressing need for quantitative biomarkers that reliably reflect MM disease severity, progression, and therapeutic response. The purpose of the study is to measure the efficacy of an electrochemical oxygen nanosensor to measure in vivo mitochondrial function in human muscle tissue, and its ability to discriminate MM patients from healthy volunteers. The data and results from this nanosensor study may contribute to current and future research, including improved diagnostic and therapeutic approaches for patients with mitochondrial disease.
This description comes directly from the study's public registry record.
Zarazuela Zolkipli-Cunningham · (267) 426 4961 · zolkipliz@chop.edu
Sara Nguyen · (267) 426-1986 · nguyens2@chop.edu
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| The Children's Hospital of Philadelphia | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04086329