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Study identifier: NCT04077099 Synced from ClinicalTrials.gov · July 29, 2026
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A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer

Condition: NSCLC  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants231
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate REGN5093 for the treatment of Non-Small Cell Lung Cancer (NSCLC) with MET alteration. The main purpose of this study is to determine the safety, tolerability, and effectiveness of REGN5093. The study has two phases. The main goal of Phase 1 is to determine a safe dose(s) of REGN5093. The main goal of phase 2 of the study is to use the REGN5093 drug dose(s) found in Phase 1 to see how well REGN5093 works to shrink tumors. The study is looking at several other research questions, including: * Side effects that may be experienced by people taking REGN5093 * How REGN5093 works in the body * How much REGN5093 is present in the blood * To see if REGN5093 works to reduce or delay the progression of cancer * How long it takes REGN5093 to work in the body

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (40)

University of Alabama at BirminghamBirmingham, Alabama, United StatesWithdrawn
University of California Irvine Medical Center - Bldg 56, RT81, Rm 241Orange, California, United StatesCompleted
Georgetown University Medical CenterWashington D.C., District of Columbia, United StatesCompleted
Moffitt Cancer Center - McKinley DriveTampa, Florida, United StatesRecruiting
University of Kentucky, Markey Cancer Center Clinical Research OrganizationLexington, Kentucky, United StatesWithdrawn
DNU_Massachusetts General Hospital_DNUBoston, Massachusetts, United StatesWithdrawn
Dana Farber Harvard Cancer Center ConsortiumBoston, Massachusetts, United StatesCompleted
Henry Ford Health SystemDetroit, Michigan, United StatesWithdrawn
Washington University School of MedicineSt Louis, Missouri, United StatesWithdrawn
NYU Cancer InstituteNew York, New York, United StatesWithdrawn
Icahn School of Medicine at Mount SinaiNew York, New York, United StatesCompleted
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesCompleted

+ 28 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04077099