Condition: Hypercholesterolemia · Hypercholesterolemia, Familial · Atherosclerosis · Sponsor: University of Cambridge
While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has been used as an early marker of drug efficacy in numerous clinical cardiovascular drug trials, as a glucose analog, its signal in the vasculature lacks inflammatory cell-specificity. Moreover, high background 18F-FDG signals from the myocardium often preclude coronary artery imaging, despite attempts to suppress myocardial tracer uptake by dietary manipulation. These limitations of 18F-FDG for measuring changes in vascular inflammation arising from drug intervention highlight important unmet needs, which might be overcome by using a somatostatin receptor subtype-2 (SST2) PET tracer.
This description comes directly from the study's public registry record.
Jason M Tarkin, MBBS PhD · +44(0)1223331504 · jt545@cam.ac.uk
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| University of Cambridge | Cambridge, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04073797