Condition: Hepatic Encephalopathy · Cirrhosis, Liver · Portal Hypertension · Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rationale: Hepatic encephalopathy (HE) is a major and common complication in patients with liver cirrhosis. HE can be classified in the extensive range of neurocognitive deterioration as minimal HE (MHE), covert HE (grade I), or overt HE (OHE, grade II-IV). Liver cirrhosis is the most common cause of portal hypertension (PH). Patients who develop complications of PH, like variceal bleeding or refractory ascites, can benefit from a Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement. Unfortunately, post-TIPS HE is a common and often severe complication. Incidence of new onset or worsening of HE after TIPS is approximately 20-45%. Currently there is no strategy to prevent post-TIPS HE.
This description comes directly from the study's public registry record.
Koos de Wit, MD · 0031-20-5668468 · leverresearch@amc.uva.nl
Always discuss trial participation with your own doctor first.
| Universitaire Ziekenhuizen Leuven | Leuven, Belgium | Recruiting |
| Academic Medical Centre | Amsterdam, Netherlands | Recruiting |
| University Medical Center Groningen | Groningen, Netherlands | Recruiting |
| Leiden University Medical Center | Leiden, Netherlands | Recruiting |
| Radboud University | Nijmegen, Netherlands | Recruiting |
| Erasmus Medical Center | Rotterdam, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04073290