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Study identifier: NCT04065399 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Condition: Acute Myeloid Leukemia · Acute Lymphoblastic Leukemia · Mixed Lineage Acute Leukemia  ·  Sponsor: Syndax Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants447
Who can joinAll sexes, 30 Days to no upper limit
Healthy volunteersNo

About this study

Phase 1 dose escalation will determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of revumenib in participants with acute leukemia. In Phase 2, participants will be enrolled in 4 indication-specific expansion cohorts to determine the efficacy, short- and long-term safety, and tolerability of revumenib.

This description comes directly from the study's public registry record.

Talk to the study team

Syndax Pharmaceuticals  ·  781-419-1400  ·  clinicaltrials@syndax.com

Always discuss trial participation with your own doctor first.

Locations (57)

City of Hope Comprehensive Cancer CenterDuarte, California, United StatesActive Not Recruiting
University Of California Care Medical Group - Norris Comprehensive Cancer Center And HospitalLos Angeles, California, United StatesCompleted
Stanford Cancer InstitutePalo Alto, California, United StatesActive Not Recruiting
University of ColoradoAurora, Colorado, United StatesRecruiting
Florida Cancer Specialists and Research InstituteSarasota, Florida, United StatesActive Not Recruiting
Moffitt Cancer CenterTampa, Florida, United StatesCompleted
Emory Winship Cancer InstituteAtlanta, Georgia, United StatesRecruiting
Children's Healthcare of AtlantaAtlanta, Georgia, United StatesCompleted
The University of Chicago Medical CenterChicago, Illinois, United StatesRecruiting
University of Iowa HospitalIowa City, Iowa, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesActive Not Recruiting
Washington University in St. Louis School of MedicineSt Louis, Missouri, United StatesRecruiting

+ 45 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04065399