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Study identifier: NCT04059172 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management

Condition: Pain, Orofacial  ·  Sponsor: University of Colorado, Denver

PhaseEARLY_Phase 1
Planned participants375
Who can joinAll sexes, 12 Years to 80 Years
Healthy volunteersYes

About this study

The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a placebo. The hypothesis is that combined ibuprofen and acetaminophen therapy will effectively provide better pain control than ibuprofen alone or a placebo after orthodontic appliance placement.

This description comes directly from the study's public registry record.

Talk to the study team

Clifton M Carey, PhD  ·  3037241046  ·  clifton.carey@cuanschutz.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Colorado, School of Dental MedicineAurora, Colorado, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04059172