Condition: Diabetes Mellitus · Cardiovascular Diseases · Insulin Sensitivity/Resistance · Sponsor: University of Alabama at Birmingham
Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the metabolic health of an individual. Low circulating level of NPs is an important contributor to increased risk for diabetes. The NP levels are relatively lower among Black individuals thus affecting their metabolic health and putting them at a higher risk for diabetes. This study aims to test the hypothesis that by augmenting NP levels using sacubitril/valsartan, among Black Individuals one can improve their metabolic health (as measured by insulin sensitivity \& energy expenditure) and help establish the role of NPs in the underlying mechanism behind increased risk for cardiometabolic disease in these population.
This description comes directly from the study's public registry record.
Nehal Vekariya, MS · 205-934-7173 · nvekariya@uabmc.edu
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| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04055428