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Study identifier: NCT04055220 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas

Condition: Bone Sarcoma · Osteosarcoma · Ewing Sarcoma  ·  Sponsor: Centre Leon Berard

PhaseNA
Planned participants168
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

Randomized, non-comparative, multicentre exploratory phase II study. Two arms concerning patients with bone sarcoma after the first line therapy: in the first arm, patients will be treated with Regorafenib for a maximum of 12 months as maintenance therapy after first line therapy, whereas in the second arm, patients will be kept under surveillance (standard of care). Regardless of their study arm, all the patients will be followed up until end of the study. The comparison between these two arms will allow to determine whether or not regorafenib is efficient for disease control, in terms of Relapse-Free Survival improvement.

This description comes directly from the study's public registry record.

Talk to the study team

Julien GAUTIER  ·  +33 426 55 68 29  ·  julien.gautier@lyon.unicancer.fr

Always discuss trial participation with your own doctor first.

Locations (16)

Hôpital Jean MinjozBesançon, FranceRecruiting
Institut BergoniéBordeaux, FranceRecruiting
Centre Oscar LambretLille, FranceRecruiting
Centre Léon BérardLyon, FranceRecruiting
APHM - Hôpital TimoneMarseille, FranceRecruiting
ICM Val d'AurelleMontpellier, FranceNot Yet Recruiting
Institut CurieParis, FranceRecruiting
APHP Hôpital CochinParis, FranceRecruiting
Centre Hospitalier Universitaire de PoitiersPoitiers, FranceNot Yet Recruiting
Centre Hospitalier Universitaire de Saint-Etienne (CHUSE)Saint-Etienne, FranceRecruiting
ICO René GauducheauSaint-Herblain, FranceRecruiting
Centre Paul Strauss - StrasbourgStrasbourg, FranceRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04055220