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Study identifier: NCT04045665 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Condition: Atrial Fibrillation · Stroke · Bleeding  ·  Sponsor: Icahn School of Medicine at Mount Sinai

PhasePhase 3
Planned participants3200
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their baseline risk profile and their treatment strategy in terms of anticoagulants or antiplatelets received. These patients will also be asked to fill out a brief decliner survey.

This description comes directly from the study's public registry record.

Talk to the study team

Jonathan Hupf  ·  (212) 659-6862  ·  Jonathan.Hupf@mountsinai.org

Always discuss trial participation with your own doctor first.

Locations (106)

CHI St. Vincent, ArkansasLittle Rock, Arkansas, United StatesRecruiting
University of Southern CaliforniaLos Angeles, California, United StatesRecruiting
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
Stanford UniversityStanford, California, United StatesRecruiting
Medical Center of AuroraAurora, Colorado, United StatesActive Not Recruiting
Western Connecticut Hospital SystemsDanbury, Connecticut, United StatesActive Not Recruiting
Yale MedicineNew Haven, Connecticut, United StatesRecruiting
MedStar Washington Hospital CenterWashington D.C., District of Columbia, United StatesRecruiting
Emory UniversityAtlanta, Georgia, United StatesRecruiting
Piedmont Healthcare Inc.Atlanta, Georgia, United StatesRecruiting
Lutheran Medical CenterFort Wayne, Indiana, United StatesActive Not Recruiting
Indiana UniversityIndianapolis, Indiana, United StatesActive Not Recruiting

+ 94 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04045665