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Study identifier: NCT04043494 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

Condition: Lymphoblastic Lymphoma, Childhood  ·  Sponsor: University Hospital Muenster

PhasePhase 3
Planned participants683
Who can joinAll sexes, N/A to 18 Years
Healthy volunteersNo

About this study

Primary objectives: * Randomization R1, all patients eligible: To examine, whether the cumulative incidence of relapses with involvement of the CNS (CNS relapse, pCICR) can be decreased by a modified induction therapy including dexamethasone (experimental arm) instead of prednisone (standard arm) * Randomization R2, only patients with high risk LBL eligible: to examine, whether the probability of event-free survival (pEFS) in these patients can be improved by receiving an intensified treatment arm versus a standard treatment arm (as used in the EURO-LB 02)

This description comes directly from the study's public registry record.

Talk to the study team

Birgit Burkhardt, Prof. Dr. Dr.  ·  +49 251 83 55696  ·  LBL2018@ukmuenster.de

Always discuss trial participation with your own doctor first.

Locations (228)

Univ.Klinik für Kinder- und Jugendheilkunde Graz, Klin. Abteilung für pädiatrische Hämato-OnkologieGraz, AustriaRecruiting
Univ.Klinik für Kinder- und Jugendheilkunde Innsbruck, Universitätsklinik für Pädiatrie IInnsbruck, AustriaRecruiting
Kepler Universitätsklinikum, Med Campus IV / OnkologieLinz, AustriaRecruiting
LKH Salzburg, Universitätsklinik für Kinder- und Jugendheilkunde, KinderonkologieSalzburg, AustriaRecruiting
St. Anna KinderspitalVienna, AustriaRecruiting
Hôpital Universitaire des Enfants Reine Fabiola (ULB), Pédiatrie hémato-oncologieBrussels, BelgiumRecruiting
University Hospital Brussels, Pediatrische oncologieBrussels, BelgiumRecruiting
Cliniques Universitaires Saint-Luc (UCL), Hématologie et oncologie pédiatriqueBrussels, BelgiumRecruiting
UZ Antwerpen Kinderhemato-oncologieEdegem, BelgiumRecruiting
University Hospital Gent Pediatrische hemato-oncologieGhent, BelgiumRecruiting
University Hospitals Leuven, Kinderhemato-oncologieLeuven, BelgiumRecruiting
CHR Citadelle Hémato - oncologie pédiatriqueLiège, BelgiumRecruiting

+ 216 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04043494