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Study identifier: NCT04040205 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Condition: Chondrosarcoma · Osteosarcoma · Soft Tissue Sarcoma  ·  Sponsor: Medical College of Wisconsin

PhasePhase 2
Planned participants44
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a single-arm, phase II study that will enroll a total of 45 subjects. All subjects will have a confirmed diagnosis of metastatic or unresectable soft tissue sarcoma or bone sarcoma. All subjects must have intact Rb, identified at the time of screening, by immunohistochemistry testing of submitted tumor specimen. Subjects will receive Abemaciclib 200 mg twice daily until progression or discontinuation criteria are met.

This description comes directly from the study's public registry record.

Talk to the study team

Medical College of Wisconsin Cancer Center Clinical Trials Office  ·  866-680-0505  ·  cccto@mcw.edu

Always discuss trial participation with your own doctor first.

Locations (4)

Mayo ClinicJacksonville, Florida, United StatesRecruiting
University of Iowa Hospitals and ClinicsIowa City, Iowa, United StatesRecruiting
Washington University in St. LouisSt Louis, Missouri, United StatesRecruiting
Froedtert Hospital & the Medical College of WisconsinMilwaukee, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04040205