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Study identifier: NCT04031677 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

Condition: Retroperitoneal Sarcoma · Liposarcoma · Leiomyosarcoma  ·  Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

PhasePhase 3
Planned participants250
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.

This description comes directly from the study's public registry record.

Talk to the study team

EORTC HQ  ·  +3227741611  ·  1809@eortc.org

Always discuss trial participation with your own doctor first.

Locations (169)

University of Alabama at Birmingham Cancer CenterBirmingham, Alabama, United StatesWithdrawn
Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesRecruiting
UCI Health-Chao Family Comp CC and Ambulatory CareIrvine, California, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
UC Irvine Health/Chao Family Comprehensive Ca CtrOrange, California, United StatesRecruiting
UCHealth University of Colorado HospitalAurora, Colorado, United StatesRecruiting
Smilow Cancer Hospital-Derby Care CenterDerby, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care Center-FairfieldFairfield, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care Center at GlastonburyGlastonbury, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care Center at GreenwichGreenwich, Connecticut, United StatesRecruiting
Smilow Cancer Hospital Care Center - GuifordGuilford, Connecticut, United StatesRecruiting

+ 157 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04031677