Condition: Peripheral Arterial Disease · Critical Limb Ischemia · Frailty · Sponsor: University of Leicester
Single-centre prospective cohort study of patients presenting with severe limb ischaemia (SLI). The primary outcome measure will be 12 month major amputation rate. A historical cohort of patients identified retrospectively will be the comparitor group used to assess the impact of a newly-established rapid-access limb salvage clinic. Primary aim: \- Determine the proportion of patients with SLI undergoing major lower limb amputation within 12 months of presentation. Secondary aims: * Assess clinically important short-, medium- and long-term outcomes in those undergoing and not undergoing amputation * Prevalence and degree of frailty and cognitive impairment * Pevalence and degree of cardiac disease (detected by stress MRI) * Establish a biobank for future biomarker analysis * Investigate the role of frailty and cognitive assessments, cardiac MRI and biomarkers in risk-stratification of patients with SLI
This description comes directly from the study's public registry record.
Rob D Sayers, MD · +44 (0)116 252 3141 · rs152@le.ac.uk
Tanya J Payne, BSc · +44 (0)116 258 3867 · tjp28@le.ac.uk
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| Glenfield Hospital Leicester | Leicester, Leicestershire, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04027244