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Study identifier: NCT04024761 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

Condition: Acute Myeloid Leukemia · Myelodysplastic Syndromes · Myeloproliferative Neoplasm  ·  Sponsor: Dana-Farber Cancer Institute

PhasePhase 1
Planned participants50
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersNo

About this study

This research study is studying cytokine induced memory-like natural killer (CIML NK) cells combined with IL-2 in adult patients (18 years of age or older) with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Myeloproliferative Neoplasms (MPN) who relapse after haploidentical hematopoietic cell transplantation (haplo-HCT) or HLA matched stem cells. This study will also study CIML NK cell infusion combined with IL-2 in pediatric patients (12 years of age or older) with AML, MDS, JMML who relapse after stem cell transplantation using HLA-matched related donor or related donor haploidentical stem cells.

This description comes directly from the study's public registry record.

Talk to the study team

Roman M. Shapiro, MD  ·  617-632-3470  ·  roman_shapiro@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04024761