Condition: Cardiogenic Shock · Sponsor: Pr Bruno LEVY
Cardiogenic shock (CS) mortality remains high (40%). Despite their frequent use, few clinical outcome data are available to guide the initial selection of vasoactive drug therapies in patients with CS. Based on experts' opinions, the combination of norepinephrine-dobutamine is generally recommended as a first line strategy. Inotropic agents increase myocardial contractility, thereby increasing cardiac output. Dobutamine is commonly recommended to be the inotropic agent of choice and levosimendan is generally used following dobutamine failure. It may represent an ideal agent in cardiogenic shock, since it improves myocardial contractility without increasing cAMP or calcium concentration. At present, there are no convincing data to support a specific inotropic agent in patients with cardiogenic shock. Our hypothesis is that the early use of levosimendan, by enabling the discontinuation of dobutamine, would accelerate the resolution of signs of low cardiac output and facilitate myocardial recovery.
This description comes directly from the study's public registry record.
Bruno LEVY, Pr · +33 3 83 15 40 84 · b.levy@chru-nancy.fr
Always discuss trial participation with your own doctor first.
| CHRU Strasbourg -Nouvel Hôpital Civil | Strasbourg, Bas-Rhin, France | Recruiting |
| AP-HM, Nord Hospital, Marseille | Marseille, Bouches du Rhône, France | Recruiting |
| CHU Caen | Caen, Calvados, France | Not Yet Recruiting |
| CHU Dijon | Dijon, Côte d'Or, France | Recruiting |
| CHU Besançon Jean Minjoz Hospital | Besançon, Doubs, France | Recruiting |
| CHU Nîmes, Carémeau Hospital | Nîmes, Gard, France | Recruiting |
| CHU Bordeaux - Hopital haut-leveque | Bordeaux, Gironde, France | Recruiting |
| CHU de Toulouse | Toulouse, Haute-Garonne, France | Recruiting |
| CHU Limoges, Dupuytren Hospital | Limoges, Haute-Vienne, France | Recruiting |
| CHU Montpellier, Arnaud de Villeneuve Hospital | Montpellier, Hérault, France | Recruiting |
| CHU Rennes, Pontchaillou Hospital | Rennes, Ille et Vilaine, France | Recruiting |
| CHU Grenoble, Michallon Hospital | La Tronche, Isère, France | Recruiting |
+ 16 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04020263