Condition: Esophagus Adenocarcinoma · Esophagus Squamous Cell Carcinoma · Gastroesophageal Junction Adenocarcinoma · Sponsor: Dallas VA Medical Center
Esophageal cancer, which has a low 5-year overall survival rate for all stages (\<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling pathways are activated in a significant proportion of esophageal cancers. Itraconazole, a widely used anti-fungal medication, has been shown to inhibit various pathways involved in esophageal cancer tumorigenesis including Hh and AKT. In this phase II clinical trial, the investigators aim to evaluate the effect of itraconazole as a neoadjuvant therapy following standard of care chemoradiation in the treatment of locoregional esophageal and gastroesophageal junction carcinomas.
This description comes directly from the study's public registry record.
David Wang, MD, PhD · 214-857-0737 · davidh.wang@va.gov
Thai Pham, MD · 214-857-1800 · thai.pham2@va.gov
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| Dallas VA Medical Center | Dallas, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04018872