Condition: STEMI · Elevated IMR (>32) · Sponsor: University of Sydney
Heart attacks are caused by a blood clot blocking the blood vessels of the heart, preventing blood getting to the heart muscle. Opening up the artery with a balloon (angioplasty) and a small mesh tube (stent) although life saving can cause this clot to break up and get washed downstream, which can make the heart attack worse. The investigators can measure the amount of damage caused to the microcirculation by calculating the IMR (Index of Microcirculatory resistance). This can be measured by a wire in the coronary artery with a pressure sensor at the tip. If the IMR is elevated, it is suggestive of extensive microcirculatory damage. A clot dissolving medicine can be administered in the artery to try and reduce the IMR which can reduce damage to the heart muscle and improve outcomes. Impaired microcirculatory perfusion in patients as a result of ST-elevation myocardial infarction (STEMI) is associated with poor clinical outcomes. This project seeks to identify patients with impaired microcirculatory perfusion after STEMI and to assess whether acute improvement in microcirculatory perfusion in these patients by the use of intracoronary thrombolytic therapy results in improved clinical outcomes.
This description comes directly from the study's public registry record.
Martin Ng, MBBS (Hons) · +614 3407 8507 · martin.ng@sydney.edu.au
Rebecca Mister · +612 9562 5000 · RESTORE-MI.Study@sydney.edu.au
Always discuss trial participation with your own doctor first.
| Bankstown-Lidcombe Hospital | Bankstown, New South Wales, Australia | Not Yet Recruiting |
| Royal Prince Alfred Hospital | Camperdown, New South Wales, Australia | Recruiting |
| Concord Repatriation General Hospital | Concord, New South Wales, Australia | Recruiting |
| Northern Beaches Hospital | Frenchs Forest, New South Wales, Australia | Not Yet Recruiting |
| Liverpool Hospital | Liverpool, New South Wales, Australia | Recruiting |
| John Hunter Hospital | New Lambton Heights, New South Wales, Australia | Recruiting |
| Prince of Wales Hospital | Randwick, New South Wales, Australia | Not Yet Recruiting |
| Wollongong Hospital | Wollongong, New South Wales, Australia | Withdrawn |
| Royal Adelaide Hospital | Adelaide, South Australia, Australia | Recruiting |
| Lyell McEwin Hospital | Elizabeth Vale, South Australia, Australia | Recruiting |
| Box Hill Hospital | Box Hill, Victoria, Australia | Recruiting |
| Jessie McPherson Private Hospital | Clayton, Victoria, Australia | Recruiting |
+ 10 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03998319