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Study identifier: NCT03981276 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders

Condition: Hereditary Spastic Paraplegia  ·  Sponsor: Dr. Rebecca Schule

PhaseN/A
Planned participants2000
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersYes

About this study

The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders in a prospective multicenter natural history study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the genetic etiology and molecular mechanisms of these diseases.

This description comes directly from the study's public registry record.

Talk to the study team

Rebecca Schüle, PD Dr.  ·  +49 7071 29  ·  rebecca.schuele-freyer@uni-tuebingen.de

Ludger Schöls, Prof. Dr.  ·  +49 7071 29  ·  ludger.schoels@uni-tuebingen.de

Always discuss trial participation with your own doctor first.

Locations (13)

University InnsbruckInnsbruck, AustriaRecruiting
German Center for Neurodegenerative Diseases (DZNE) BonnBonn, GermanyRecruiting
University of ErlangenErlangen, GermanyRecruiting
University Medicine EssenEssen, GermanyRecruiting
University GöttingenGöttingen, GermanyRecruiting
University HeidelbergHeidelberg, GermanyNot Yet Recruiting
University of LübeckLübeck, GermanyNot Yet Recruiting
German Center for Neurogedenerative Diseases (DZNE) MagdeburgMagdeburg, GermanyRecruiting
German Center for Neurodegenerative Diseases (DZNE) MünchenMünchen, GermanyRecruiting
University of RegensburgRegensburg, GermanyNot Yet Recruiting
German Center for Neurodegenerative Diseases (DZNE) RostockRostock, GermanyNot Yet Recruiting
University of Tübingen and German Center for Neurodegenerative Diseases (DZNE) TübingenTübingen, GermanyRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03981276