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Study identifier: NCT03970096 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

Condition: Acute Leukemia · Acute Lymphoblastic Leukemia · Acute Myeloid Leukemia  ·  Sponsor: Fred Hutchinson Cancer Center

PhasePhase 2
Planned participants120
Who can joinAll sexes, 1 Year to 60 Years
Healthy volunteersNo

About this study

This phase II trial investigates two strategies and how well they work for the reduction of graft versus host disease in patients with acute leukemia or MDS in remission. Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient, they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient's immune cells and help destroy any remaining cancer cells.

This description comes directly from the study's public registry record.

Talk to the study team

Marie Bleakley  ·  206-667-6572  ·  mbleakle@fredhutch.org

Always discuss trial participation with your own doctor first.

Locations (3)

Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, Pennsylvania, United StatesRecruiting
Fred Hutch/University of Washington Cancer ConsortiumSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03970096