Condition: ARDS · Sponsor: Unity Health Toronto
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a basket trial design examines a single intervention in multiple disease populations. CAVIARDS consists of an identical 2-arm mechanical ventilation protocol implemented in two different study populations (COVID-19 and non-COVID-19 patients). As per a typical basket trial design, the operational structure of both the COVID-19 substudy (CAVIARDS-19) and non-COVID-19 substudy (CAVIARDS-all) is shared (recruitment, procedures, data collection, analysis, management, etc.).
This description comes directly from the study's public registry record.
Laurent Brochard, MD · 416-864-6060 · laurent.brochard@unityhealth.to
Always discuss trial participation with your own doctor first.
| New York University Grossman School of Medicine | New York, New York, United States | Recruiting |
| Centro de Educación Médica e Investigaciones Clínicas Dr Norberto Quirno (CEMIC) | Buenos Aires, Argentina | Recruiting |
| Complejo Médico Policía Federal Argentina Churruca Visca | Buenos Aires, Argentina | Recruiting |
| Hospital Británico de Buenos Aires | Buenos Aires, Argentina | Recruiting |
| Sanatorio Anchorena Recoleta | Buenos Aires, Argentina | Recruiting |
| Sanatorio Mater Dei | Buenos Aires, Argentina | Recruiting |
| Sanatorio Anchorena San Martín | San Martin, Argentina | Recruiting |
| St. Michael's Hospital | Toronto, Canada | Recruiting |
| Toronto General Hospital | Toronto, Canada | Recruiting |
| Toronto Western Hospital | Toronto, Canada | Recruiting |
| Pontificia Universidad Católica de Chile | Santiago, Chile | Recruiting |
| CHU Amiens-Picardie | Amiens, France | Recruiting |
+ 21 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03963622