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Study identifier: NCT03938987 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Anti-CD19, Dual Co-stimulatory (4-1BB, CD3ζ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)

Condition: Relapsed Non Hodgkin Lymphoma · Relapsed Adult ALL · Relapsed Pediatric ALL  ·  Sponsor: University of Alberta

PhasePhase 1/Phase 2
Planned participants63
Who can joinAll sexes, 2 Years to 70 Years
Healthy volunteersNo

About this study

Autologous, unselected CD3+ lymphocytes collected from apheresis, transfected with a lentiviral vector containing a 2nd generation chimeric antigen receptor (CAR) consisting of a scFv recognizing CD19 and dual co-stimulatory intracellular signaling domains (4-1BB and CD3ζ).

This description comes directly from the study's public registry record.

Talk to the study team

Zack Breckenridge  ·  7803917687  ·  zackariah.breckenridge@ahs.ca

Always discuss trial participation with your own doctor first.

Locations (6)

Foothills Medical CentreCalgary, Alberta, CanadaNot Yet Recruiting
Tom Baker Cancer CentreCalgary, Alberta, CanadaNot Yet Recruiting
Alberta Children's HospitalCalgary, Alberta, CanadaNot Yet Recruiting
Cross Cancer InstituteEdmonton, Alberta, CanadaRecruiting
Stollery Children's HospitalEdmonton, Alberta, CanadaNot Yet Recruiting
University of Alberta HospitalEdmonton, Alberta, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT03938987