Condition: Obstructive Sleep Apnea · Sponsor: ResMed
During sleep, the muscle tonus in the oropharyngeal space is lost, the tongue might fall back andthe volume of the pharynx decreases. Air cannot pass through as it would in the awake state and thus airflow limitations occur. The person asleep might compensate the flow limitation by breathing faster, which causes the soft tissue to vibrate (= snoring). Further narrowing of the airways can lead to obstructive apneas (complete airway collapse and stopping of airflow). First line therapy for obstructive sleep apnea (OSA) is positive airway pressure (PAP) that keeps the airways open with a pneumatic splint. Since PAP involves wearing a facial mask that applies air pressure into the airways, some patients cannot tolerate this therapy. These patients might be candidates for an alternative treatment approach with a mandibular advancement device (MAD).
This description comes directly from the study's public registry record.
Oliver Munt, PhD · +491629056360 · oliver.munt@resmed.de
Always discuss trial participation with your own doctor first.
| Schlaf- und Beatmungszentrum Blaubeuren | Blaubeuren Abbey, Badden-Württemberg, Germany | Not Yet Recruiting |
| Ruhrlandklinik Essen | Essen, North Rhine-Westphalia, Germany | Recruiting |
| Zentrum für Schlafmedizin Dr. Warmuth | Berlin, Germany | Not Yet Recruiting |
| Universitätsklinikum Regensburg - Klinik für Innere Medizin II | Regensburg, Germany | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT03924817