Condition: Locally Advanced Malignant Solid Neoplasm · Metastatic Malignant Solid Neoplasm · Sponsor: National Cancer Institute (NCI)
This phase II trial studies the side effects of durvalumab when given together with chemotherapy in treating patients with solid tumors that have spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine hydrochloride, pegylated liposomal doxorubicin hydrochloride, capecitabine, carboplatin, paclitaxel, and nab-paclitaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy with durvalumab may improve how immune cells respond and attack tumor cells.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| National Cancer Institute Developmental Therapeutics Clinic | Bethesda, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03907475