Condition: Metastatic Castration-resistant Prostate Cancer (mCRPC) · Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) · Sponsor: Karolinska Institutet
ProBio is an international, outcome-adaptive, multi-arm, open-label, multiple assignment randomized biomarker driven platform trial in patients with metastatic prostate cancer. Patients will be randomized to control or experimental treatment arms. Patients in the control arm will receive standard of care following national guidelines. Patients in the experimental arm will be randomized to treatments based on a biomarker signature inferred from diagnostic tissue or liquid biopsy profiling. The predefined biomarker signatures are tumor properties or mutations in genes/pathways with previously demonstrated clinical validity (e.g. prognostic value or association with treatment response). The biomarker signatures are identified using a hybridisation capture gene panel specifically designed for prostate cancer.
This description comes directly from the study's public registry record.
Berit Larsson, MSc · +46 8 52482576 · berit.larsson@ki.se
Henrik Grönberg, Professor · +46 70 3411356 · Henrik.gronberg@ki.se
Always discuss trial participation with your own doctor first.
| OLV Ziekenhuis Aalst | Aalst, Belgium | Recruiting |
| GZA Sint-Augustinus | Antwerp, Belgium | Recruiting |
| AZ Sint-Jan AV | Bruges, Belgium | Recruiting |
| AZ Sint-Lucas | Bruges, Belgium | Recruiting |
| Ziekenhuis Oost-Limburg | Genk, Belgium | Recruiting |
| University Hospital Ghent | Ghent, Belgium | Recruiting |
| AZ Jan Palfijn Ziekenhuis | Ghent, Belgium | Not Yet Recruiting |
| Jessa ziekenhuis | Hasselt, Belgium | Recruiting |
| AZ Groeninge | Kortrijk, Belgium | Recruiting |
| University Hospital Luik | Liège, Belgium | Recruiting |
| AZ Damiaan | Ostend, Belgium | Recruiting |
| VITAZ | Sint-Niklaas, Belgium | Recruiting |
+ 20 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03903835