Condition: Acne Vulgaris · Sponsor: Centre for Human Drug Research, Netherlands
The combined bacteriostatic and immunomodulatory effects of erythromycin and clindamycin will be explored. Treatment effects will be extensively characterized by conventional methods including lesion counts, global assessment scales and visual grading as well as state-of-the-art methodology, including multi-modal photo analysis, perfusion by laser speckle contrast imaging, analysis of local skin surface, biopsy biomarkers and skin microbiota. This extensive response profiling, combined with the mechanistic insights from concurrent in vitro and in vivo studies in healthy volunteer challenges, will increase the understanding of erythromycin's and clindamycin's effects in acne vulgaris.
This description comes directly from the study's public registry record.
Robert Rissmann, PharmD, PhD · +31 71 5246 400 · clintrials@chdr.nl
Diana Noort · +31 71 5246 400 · clintrials@chdr.nl
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| Centre for Human Drug Research | Leiden, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03883269