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Study identifier: NCT03859297 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Mechanisms of Rumination Change in Adolescent Depression

Condition: Major Depressive Disorder · Mood Disorders  ·  Sponsor: Ohio State University

PhaseNA
Planned participants183
Who can joinAll sexes, 14 Years to 17 Years
Healthy volunteersNo

About this study

This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.

This description comes directly from the study's public registry record.

Talk to the study team

Scott A Langenecker, Ph.D.  ·  734-276-3889  ·  scott.langenecker@osumc.edu

Caty Escobar, M.S.  ·  301-648-3426  ·  caty.escobar@osumc.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Nationwide Children's HospitalColumbus, Ohio, United StatesRecruiting
The Ohio State UniversityColumbus, Ohio, United StatesRecruiting
University of UtahSalt Lake City, Utah, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03859297