Condition: Polycystic Ovary Syndrome · Hypothalamic Amenorrhea · Sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Reproduction requires from women enough energy depots to warrant an adequate nutritional supply to the fetus. Hence, adipose tissue is able to communicate with female hypothalamic-pituitary-ovary axis. The hypothesis of the project is that abnormalities in the quantity (absolute and relative to lean body mass), distribution and/or function of adipose tissue are associated with functional forms of female gonadal dysfunction in predisposed women, in a spectrum of anomalies that go from hypothalamic amenorrhea to the polycystic ovary syndrome (PCOS). To challenge this hypothesis, the investigators will study 5 groups of 10 women each: women with exercise-associated hypothalamic amenorrhea, women without ovulatory dysfunction that exercise equally, non-hyperandrogenic patients with PCOS, hyperandrogenic patients with PCOS, and healthy control women comparable to those with PCOS. The aims of the study will be: Primary objective: To identify novel signalling factors originating from adipose tissue and muscle using targeted and nontargeted evaluation of the proteome and of gene expression of superficial subcutaneous fat, deep subcutaneous fat (which mimics visceral adipose tissue) and skeletal muscle. Secondary objectives: 1. To study the serum adipokine profile - including those identified by the primary objective - and circulating gut hormones during fasting and after a glucose load in the 5 groups of women, and their associations with sexual hormones and body fat distribution.…
This description comes directly from the study's public registry record.
Alejandra Quintero Tobar · 34913369029 · mariaalejandra.quintero@salud.madrid.org
Sara de Lope Quiñones · 34913369029 · sara.lope@salud.madrid.org
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| Endocrinology and Nutrition | Madrid, Madrid, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03841981