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Study identifier: NCT03838042 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies

Condition: CNS Tumor · Solid Tumor  ·  Sponsor: University Hospital Heidelberg

PhasePhase 1/Phase 2
Planned participants91
Who can joinAll sexes, 2 Years to 21 Years
Healthy volunteersNo

About this study

The aim of this trial is to determine preliminary activity of the combination treatment with nivolumab and entinostat in children and adolescents with high risk refractory/relapsed/progressive tumors harboring a high mutational load, focal MYC(N) amplification or ATRT-MYC subgroup as well as tumors with high tumor infiltrating lymphocytes (TILs) or a tertiary lymphoid structure (TLS).

This description comes directly from the study's public registry record.

Talk to the study team

Venukah Schäfer  ·  +496221 56 7267  ·  venukah.schaefer@kitz-heidelberg.de

Melanie Heiß  ·  +496221 56 7255  ·  melanie.heiss@kitz-heidelberg.de

Always discuss trial participation with your own doctor first.

Locations (14)

Sydney Children's HospitalRandwick, New South Wales, AustraliaRecruiting
Children's Hospital at WestmeadWestmead, New South Wales, AustraliaRecruiting
Royal Children's HospitalParkville, Victoria, AustraliaRecruiting
Perth Children's HospitalNedlands, Western Australia, AustraliaRecruiting
St. Anna Children's HospitalVienna, AustriaRecruiting
Institut CurieParis, FranceRecruiting
Augsburg University HospitalAugsburg, GermanyRecruiting
Charité University Medicine BerlinBerlin, GermanyRecruiting
Essen University HospitalEssen, GermanyRecruiting
Hannover Medical SchoolHanover, GermanyRecruiting
Hopp Children's Cancer Center Heidelberg (KiTZ)Heidelberg, GermanyRecruiting
Prinses Máxima CentrumUtrecht, NetherlandsRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03838042