Condition: Disorder of Consciousness · Paralysis · Motor Neuron Disease · Sponsor: University of Ulster
STUDY OVERVIEW Brain injury can result in a loss of consciousness or awareness, to varying degrees. Some injuries are mild and cause relatively minor changes in consciousness. However, in severe cases a person can be left in a state where they are "awake" but unaware, which is called unresponsive wakefulness syndrome (UWS, previously known as a vegetative state). Up to 43% of patients with a UWS diagnosis, regain some conscious awareness, and are then reclassified as minimally conscious after further assessment by clinical experts. Many of those in the minimally conscious state (MCS) and all with unresponsive wakefulness syndrome (UWS) are incapable of providing any, or consistent, overt motor responses and therefore, in some cases, existing measures of consciousness are not able to provide an accurate assessment. Furthermore, patients with locked-in syndrome (LIS), which is not a disorder of consciousness as patients are wholly aware, also, struggle to produce overt motor responses due to paralysis and anarthria, leading to long delays in accurate diagnoses using current measures to determine levels of consciousness and awareness. There is evidence that LIS patients, and a subset of patients with prolonged disorders of consciousness (DoC), can imagine movement (such as imagining lifting a heavy weight with their right arm) when given instructions presented either auditorily or visually - and the pattern of brain activity that they produce when imagining these movements, can …
This description comes directly from the study's public registry record.
Damien Coyle, PhD · +44 28 7167 5170 · dh.coyle@ulster.ac.uk
Naomi du Bois, PhD · +44 28 7167 5321 · n.du-bois@ulster.ac.uk
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| National Rehabilitation Hospital of Ireland | Dublin, Ireland | Not Yet Recruiting |
| Castel Froma Neuro Care | Warwick, Warwickshire, United Kingdom | Recruiting |
| Northern Health and Social Care Trust | Antrim, United Kingdom | Recruiting |
| Barnsley Hospital NHS Foundation Trust | Barnsley, United Kingdom | Recruiting |
| Belfast Health and Social Care Trust | Belfast, United Kingdom | Recruiting |
| Frenchay Brain Injury Rehabilitation Centre | Bristol, United Kingdom | Recruiting |
| NHS Lothian | Edinburgh, United Kingdom | Recruiting |
| Hull University Teaching Hospitals NHS Trust | Hull, United Kingdom | Recruiting |
| The Walton Centre NHS Foundation Trust | Liverpool, United Kingdom | Recruiting |
| The Huntercombe Group | London, United Kingdom | Recruiting |
| Royal Hospital for Neuro-Disability | London, United Kingdom | Recruiting |
| Imperial College Healthcare NHS Trust | London, United Kingdom | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03827187