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Study identifier: NCT03824483 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)

Condition: Chronic Lymphocytic Leukemia (CLL) · Small Lymphocytic Leukemia (SLL)  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants230
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to determine the rate of minimum residual disease (MRD) negative response (i.e. the rate of no evidence of disease) of the study drugs, zanubrutinib, obinutuzumab, and venetoclax, given in combination as a treatment for CLL and/or SLL.

This description comes directly from the study's public registry record.

Talk to the study team

Andrew Zelenetz, MD, PhD  ·  212-639-2656  ·  zeleneta@mskcc.org

Anthony Mato, MD  ·  212-639-8596

Always discuss trial participation with your own doctor first.

Locations (8)

Northwestern UniversityEvanston, Illinois, United StatesRecruiting
Massachusetts General Hospital (Data Collection and Specimen Analysis)Boston, Massachusetts, United StatesRecruiting
Memorial Sloan Kettering at Basking RidgeBasking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering MonmouthMiddletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering CommackCommack, New York, United StatesRecruiting
Memorial Sloan Kettering WestchesterHarrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering NassauUniondale, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03824483