Condition: Coronary Stenosis · Sponsor: Insel Gruppe AG, University Hospital Bern
Significant left main (LM) stenosis is associated with a poor prognosis, therefore, adequate judgement of the prognostic significance of LM stenosis is essential to improve patients' prognosis. Recently, fractional flow reserve (FFR) has become widespread practice and carries a Class Ia recommendation to assess functional significance of intermediate coronary stenosis in patients with stable angina. Intravascular ultrasound (IVUS)-derived minimum lumen area (MLA) represents an accurate measure to determine LM significance as shown in multiple studies, while optical coherence tomography (OCT) ,which is a novel intracoronary imaging method with a greater spatial resolution (15μm vs. 100μm), faster image acquisition and facilitated image interpretation, OCT derived-MLA has never been validated against FFR and accordingly, it is not mentioned in the current guidelines for myocardial revascularization. Coronary computed tomography angiography (CTA) has emerged as a noninvasive alternative of coronary angiography with its excellent negative predictive value, while the positive predictive value of CTA is limited. Computational fluid dynamics is an emerging method that enables prediction of blood flow in coronary arteries and calculation of FFR from computed tomography (FFRCT) noninvasively. Noninvasive and accurate assessment of functional significance would bring a great benefit for patients with LM stenosis, however, there are no data to evaluate the diagnostic accuracy of FFRCT f…
This description comes directly from the study's public registry record.
Lorenz Raeber, Prof. MD PhD · +41316322111 · lorenz.raeber@insel.ch
Hiroki Shinutani, MD · +41316322111 · hiroki.shibutani@extern.insel.ch
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| Centre Hospitalier Universitaire de Clermont-Ferrand | Clermont-Ferrand, France | Recruiting |
| Institute Mutualiste Montsouris | Paris, France | Recruiting |
| Centre Cardiologique du Nord | Saint-Denis, France | Recruiting |
| Universitätsklinikum Giessen Justus-Liebig Universität | Giessen, Hesse, Germany | Recruiting |
| Friedrich Alexander Universität (FAU) , Medizinische Klinik 2 , Kardiologie und Angiologie | Erlangen, Germany | Recruiting |
| Ageo Central General Hospital | Ageo, Japan | Recruiting |
| Gifu heart center | Gifu, Japan | Recruiting |
| Department of Cardiovascular Medicine Shinshu University School of Medicine | Nagano, Japan | Recruiting |
| Kansai Medical University, | Osaka, Japan | Recruiting |
| Medical Corporation Ouyuukai Tokorozawa Heart Center | Saitama, Japan | Recruiting |
| Sapporo Higashi Tokushukai Hospital | Sapporo, Japan | Recruiting |
| Inselspital | Bern, Switzerland | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03820492