Condition: Acute Leukemia · Acute Myeloid Leukemia · Myelodysplastic Syndromes · Sponsor: Children's Hospital of Philadelphia
The major morbidities of allogeneic hematopoietic stem cell transplant with non-human leukocyte antigen (HLA) matched siblings are graft vs host disease (GVHD) and life threatening infections. T depletion of the donor hematopoietic stem cell graft is effective in preventing GVHD, but immune reconstitution is slow, increasing the risk of infections. An addback of donor CD45RA (naive T cells) depleted cells may improve immune reconstitution and help decrease the risk of infections.
This description comes directly from the study's public registry record.
Megan Atkinson · 215-590-2820 · cttsbmtintake@chop.edu
Patricia Hankins, BSN, RN · 215-590-5168 · hankinsp@chop.edu
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| Children's Hospital of Philadelphia | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03810196