Condition: Alzheimer Disease · Sponsor: University of Alabama at Birmingham
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic tau deposition using the PET tracer AV-1451 in participants in the UAB-ADC cohort. The amount and distribution of AV-1451 in the brain will be correlated to demographic, clinical, genetic, and biospecimen data acquired through the separate ongoing UAB-ADC study. Assessment of interactions between race and vascular risk factors, brain tau levels measured with AV-1451-PET, and cognitive status will be the primary outcome of this imaging study. Individuals participating in this AV-1451-PET/MRI study will also be enrolled in an ongoing \[C-11\]PiB-PET/MRI study (IRB-300001005, IND-138128), and their amyloid, tau and cognitive statuses will be compared in terms of race and vascular risk factors.
This description comes directly from the study's public registry record.
Chinara Dosse · (205) 934-4501 · cdosse@uabmc.edu
Carol Chambless · (205) 975-9569 · cchambless@uabmc.edu
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| UAB | Birmingham, Alabama, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03809351