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Study identifier: NCT03801876 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Condition: Clinical Stage I Esophageal Adenocarcinoma AJCC v8 · Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8 · Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8  ·  Sponsor: NRG Oncology

PhasePhase 3
Planned participants300
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This trial studies how well proton beam radiation therapy compared with intensity modulated photon radiotherapy works in treating patients with stage I-IVA esophageal cancer. Proton beam radiation therapy uses a beam of protons (rather than x-rays) to send radiation inside the body to the tumor without damaging much of the healthy tissue around it. Intensity modulated photon radiotherapy uses high-energy x-rays to deliver radiation directly to the tumor without damaging much of the healthy tissue around it. It is not yet known whether proton beam therapy or intensity modulated photon radiotherapy will work better in treating patients with esophageal cancer.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (96)

Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United StatesActive Not Recruiting
Mayo Clinic in ArizonaScottsdale, Arizona, United StatesActive Not Recruiting
University of Arkansas for Medical SciencesLittle Rock, Arkansas, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, Florida, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, Florida, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at DoralDoral, Florida, United StatesRecruiting
University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, Florida, United StatesRecruiting
Miami Cancer InstituteMiami, Florida, United StatesRecruiting
UM Sylvester Comprehensive Cancer Center at KendallMiami, Florida, United StatesRecruiting
Orlando Health Cancer InstituteOrlando, Florida, United StatesActive Not Recruiting
UM Sylvester Comprehensive Cancer Center at PlantationPlantation, Florida, United StatesRecruiting
Emory Proton Therapy CenterAtlanta, Georgia, United StatesActive Not Recruiting

+ 84 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03801876