One Week Versus Three Week in Adjuvant Radiotherapy in Breast Cancer

Background:Moderate three week hypofractionated adjuvant radiotherapy schedule is a standard care in breast cancers. A five day schedule has been demonstrated to be iso-toxic as a standard three week schedule. Recently studies have also demonstrated the safety and feasibility of simultaneous integrated boost in this setting. This randomized trial will investigate if a one-week course of hypofractionated breast radiotherapy is non-inferior to a three week course. Aim: To determine if one-week schedule of adjuvant radiotherapy in breast cancer is non-inferior to a three week schedule. Primary Objective: Locoregional Recurrence Rate (LRR) (Cumulative proportion of patients with locoregional recurrence) at 5 years Secondary Objective: 1. Overall survival (OS) (Time from randomization to death) 2. Invasive Disease-free survival (iDFS) (Time from randomization to any invasive disease recurrence, death due to any cause or second invasive malignancy) 3. Late adverse events (AE) 4. Quality of Life (QoL) Hypothesis: 1. 1 week schedule will be non-inferior to a three week schedule for Locoregional Recurrence Rate 2. 1 week schedule will be non-inferior to a three week schedule for OS 3. 1 week schedule will be not result in worse late adverse events as compared to 3 week schedule 4. Proportion of patients decrease in quality of life will not differ between the two arms at 12 months Design: Open-label, parallel group, two arm, randomised, phase III, non-inferiority trial. Populat…

This description comes directly from the study's public registry record.

Sanjoy Chatterjee, FRCR  ·  9038161825  ·  sanjoy.chatterjee@tmckolkata.com

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