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Study identifier: NCT03779854 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

Condition: Acute Biphenotypic Leukemia · Acute Leukemia · Acute Leukemia of Ambiguous Lineage  ·  Sponsor: Fred Hutchinson Cancer Center

PhasePhase 2
Planned participants68
Who can joinAll sexes, 6 Months to 26 Years
Healthy volunteersYes

About this study

This phase II trial studies how well naive T-cell depletion works in preventing chronic graft-versus-host disease in children and young adults with blood cancers undergoing donor stem cell transplant. Sometimes the transplanted white blood cells from a donor attack the body's normal tissues (called graft versus host disease). Removing a particular type of T cell (naive T cells) from the donor cells before the transplant may stop this from happening.

This description comes directly from the study's public registry record.

Talk to the study team

Marie Bleakley  ·  206-667-6572  ·  mbleakle@fredhutch.org

Always discuss trial participation with your own doctor first.

Locations (10)

Children's Hospital of Los AngelesLos Angeles, California, United StatesRecruiting
Children's National Medical CenterWashington D.C., District of Columbia, United StatesWithdrawn
Children's Healthcare of AtlantaAtlanta, Georgia, United StatesNot Yet Recruiting
University of Iowa/Holden Comprehensive Cancer CenterIowa City, Iowa, United StatesRecruiting
Dana Farber / Boston Children's HospitalBoston, Massachusetts, United StatesNot Yet Recruiting
UH Rainbow Babies and Children's Hospital (University Hospitals Cleveland Medical Center)Cleveland, Ohio, United StatesNot Yet Recruiting
Cleveland Clinic FoundationCleveland, Ohio, United StatesRecruiting
Oregon Health and Science UniversityPortland, Oregon, United StatesRecruiting
Children's Hospital of Pittsburgh of UPMCPittsburgh, Pennsylvania, United StatesRecruiting
Fred Hutch/University of Washington Cancer ConsortiumSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03779854