Condition: Urogenital Prolapse · Sponsor: University Hospital, Lille
Urogenital prolapse is a frequent and invalidating pathology in women, involving the anterior vaginal wall and the uterus in most cases. Posterior vaginal wall prolapse is present in only 50% of cases. Surgery is an option for women with troublesome prolapse. A woman's lifetime risk of undergoing surgery for pelvic organ prolapse (POP) surgery by the age of 80 is around 19%. Laparoscopic sacrocolpopexy (LS) with synthetic non-absorbable mesh is considered the gold standard, with a composite success rate of 85% at one year (Prospere study). Based on early experience and historical habits, a prerectal mesh was used to be systematically placed in the rectovaginal space, in addition to the anterior and apical mesh placed in the vesicovaginal space, in order to prevent de-novo posterior prolapse (reported rates up to 33%). The benefit of preventive prerectal mesh is questionned on the basis of a single retrospective study comparing 68 LS with double-mesh (anterior \& posterior, DM) to 32 LS with a single anterior mesh (SAM): posterior recurrence rates were respectively 5.9 vs. 31.3% (p\<0,01), and total recurrence rates 16.2 vs. 43.8% (p\<0.01). However, as this difference was not significant in the subgroup of patients without associated cervicocystopexy, the authors concluded that the risk of posterior failure was only due to the cervicocystopexy itself (anti-urinary incontinence procedure which has been abandoned since). On the other hand, a prerectal mesh increases the risk …
This description comes directly from the study's public registry record.
Jean-Philippe LUCOT, MD,PhD · (0)3 21 45 62 · lucot.jean-philippe@ghicl.net
Always discuss trial participation with your own doctor first.
| Hopital Estaing | Clermont-Ferrand, France | Recruiting |
| Ch Dunkerque | Dunkirk, France | Recruiting |
| Hopital Saint-Louis - La Rochelle | La Rochelle, France | Recruiting |
| Clinique Du Pre | Le Mans, France | Recruiting |
| Hop Jeanne de Flandre Chu Lille | Lille, France | Recruiting |
| Hopital Saint Vincent - Saint Antoine | Lille, France | Recruiting |
| Chu de Nice Hopital de L'Archet | Nice, France | Recruiting |
| Chu Nimes - Nimes | Nîmes, France | Recruiting |
| Chi Poissy St Germain Site de Poissy | Poissy, France | Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT03766048