Condition: Fibromyalgia · Chronic Fatigue Syndrome · Multiple Sclerosis · Sponsor: University of Alabama at Birmingham
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary objective of this study is to determine if pain and fatigue patients have higher levels of neuroinflammation than HC individuals as measured with \[F-18\]DPA-714-PET/MRI.
This description comes directly from the study's public registry record.
Jared Younger, PhD · 205-975-5907 · youngerlab@uab.edu
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| University of Alabama at Birmingham Medical Center | Birmingham, Alabama, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03759522