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Study identifier: NCT03728478 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

STep-up and Step-down Therapeutic Strategies in Childhood ARthritiS

Condition: Oligoarthritis, Juvenile · Polyarthritis, Juvenile, Rheumatoid Factor Negative  ·  Sponsor: Istituto Giannina Gaslini

PhasePhase 3
Planned participants260
Who can joinAll sexes, 2 Years to 17 Years
Healthy volunteersNo

About this study

This study aims to compare the effectiveness of a conventional therapeutic regimen, based on treatment escalation (step-up strategy) and driven by the treat-to-target approach, with that of an early aggressive intervention based on the initial start of a combination of conventional and biological DMARDs (step-down strategy).

This description comes directly from the study's public registry record.

Talk to the study team

Alessandro Consolaro, MD, PhD  ·  01056362729  ·  alessandroconsolaro@gaslini.org

Always discuss trial participation with your own doctor first.

Locations (1)

IRCCS Istituto Giannina GasliniGenova, GE, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT03728478