Condition: Typhoid and/or Cholera Vaccination · Sponsor: University of Maryland, Baltimore
This is an open-label, non-randomized study. The purpose of this study is to better understand how vaccines against typhoid fever and cholera affect the normal immune system and bacteria in the intestine. Patients having standard-of-care endoscopies (colonoscopy and/or esophagogastroduodenoscopy (EGD)) will be divided into 3 groups: Group 1: Vivotif typhoid vaccination and/or Vaxchora cholera vaccination then endoscopy Group 2: Endoscopy, then Vivotif typhoid vaccination and/or Vaxchora cholera vaccination, then follow-up endoscopy Group 3: Endoscopy without vaccination. Both vaccines used in this study are licensed by the Food and Drug Administration (FDA) for travelers to developing countries. Volunteers will be asked to donate tissue, blood, saliva and stool samples for studying how the body responds to the typhoid and/or cholera vaccine.
This description comes directly from the study's public registry record.
Rosary Zara Necesario, RN · 410-706-6156 · rnecesario@som.umaryland.edu
Always discuss trial participation with your own doctor first.
| University of Maryland, Baltimore, Center for Vaccine Development and Global Health | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03705585