Condition: Dyspnea · Sponsor: CHOUIHED Tahar
The management of chest pain has revolutionized its prognosis, primarily by improving urgent diagnosis of myocardial infarction. Currently, acute dyspnea is twice as frequent as chest pain and its associated mortality is much higher (16% of acute dyspnea admitted to emergency departments (ED) ). Inappropriate treatment of acute dyspnea in the ED is frequent (30%) and is associated with a tripling of intra-hospital mortality after adjustment for confounding factors (2.83, IC 1.48 to 5.41, p=0.002). Other elements have also highlighted the importance of a quick and appropriate acute dyspnea diagnosis: * The 2015 European Guidelines on acute heart failure emphasize the need for appropriate treatment within 90 minutes after the first medical contact. * Inadequate treatment of chronic bronchitis decompensation is associated with a doubling of intra-hospital mortality. * An initiation of antibiotic treatment within 4 hours of admission for pneumonia is recommended. * 30% of pulmonary embolisms are not diagnosed during the initial emergency department visit, whereas their mortality in the absence of treatment is 25%. Lung, venous and (simplified) cardiac ultrasound is associated with improved diagnostic performance in ED. However, no ultrasound algorithm dedicated to emergency physicians has been formally validated. The Blue Protocol (Lichtenstein et al., Chest 2008) has been validated in intensive care patients with very different phenotypes than those admitted to the ED. Pivett…
This description comes directly from the study's public registry record.
Tahar CHOUIHED, MD · (0)3 83 85 14 96 · t.chouihed@chru-nancy.fr
Nicolas GIRERD, MD PhD · n.girerd@chru-nancy.fr
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| CH de Chalons en Champagne | Châlons-en-Champagne, France | Recruiting |
| Hôpital Simone Veil | Eaubonne, France | Recruiting |
| CHRU Nancy | Nancy, France | Recruiting |
| AP-HP - Hôpital Cochin | Paris, France | Recruiting |
| AP-HP - Hôpital Lariboisière | Paris, France | Recruiting |
| CH de Sarreguemines | Sarreguemines, France | Withdrawn |
| CHRU de Strasbourg, Hôpital de Hautepierre | Strasbourg, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03691857